Invitrogen™ LGI4 Polyclonal Antibody

Catalog No.	Quantity
PIPA560416	100 μL

Catalog No. PIPA560416 Supplier Invitrogen™ Supplier No. PA560416

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SMFRLLQQLP SRGAHVFQPL LIARDQLAIL GSDFAFSQVL RLEPDKGLLE PLQELGPPAL VAPRAFAHIT MAGRRFLFAA CFKGPTQIYQ HHEIDLSA Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Specifications

• Antigen: LGI4
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: LGI4
• Gene Accession No.: Q8N135
• Gene Alias: clp; leucine rich repeat LGI family member 4; leucine-rich glioma inactivated protein 4; leucine-rich glioma-inactivated gene 4; leucine-rich glioma-inactivated protein 4; Leucine-rich repeat LGI family member 4; leucine-rich repeat LGI family, member 4; LGI1-like protein 3; LGI4; Lgil3; UNQ6515/PRO21485
• Gene Symbols: LGI4
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human LGI4. Recombinant protein control fragment (Product #RP-99116).
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 163175
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG