Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ LGI4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520514

Catalog No. PIPA520514


Only null left
Add to Cart

Description

Description

A suggested positive control is rat brain tissue lysate. PA5-20514 can be used with blocking peptide PEP-0634.

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LGI4
Polyclonal
Unconjugated
LGI4
clp; leucine rich repeat LGI family member 4; leucine-rich glioma inactivated protein 4; leucine-rich glioma-inactivated gene 4; leucine-rich glioma-inactivated protein 4; Leucine-rich repeat LGI family member 4; leucine-rich repeat LGI family, member 4; LGI1-like protein 3; LGI4; Lgil3; UNQ6515/PRO21485
Rabbit
Antigen affinity chromatography
RUO
163175, 243914, 361549
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8K1S1, Q8N135
LGI4
A 17 amino acid peptide from near the carboxy terminus of human LGI4.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
Safety and Handling

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.