LGI4 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-8448	100 μL

Catalog No. 50-198-8448 Supplier Bioss Supplier No. BS8303R

Description

Rabbit Polyclonal Antibody

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Specifications

• Antigen: LGI4
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: LGI4
• Gene Accession No.: Q8N135
• Gene Alias: clp; leucine rich repeat LGI family member 4; leucine-rich glioma inactivated protein 4; leucine-rich glioma-inactivated gene 4; Leucine-rich glioma-inactivated protein 4; Leucine-rich repeat LGI family member 4; leucine-rich repeat LGI family, member 4; LGI1-like protein 3; Lgi4; Lgil3; UNQ6515/PRO21485
• Gene Symbols: LGI4
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human LGI4.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 163175
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG