Invitrogen™ LGMN Monoclonal Antibody (312114)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524032

Catalog No. PIMA524032

Description

In direct ELISAs, no cross-reactivity with recombinant mouse Legumain is observed. This antibody recognizes the pro form of human Legumain and does not recognize the mature form (aa 18-323). Reconstitute at 0.5 mg/mL in sterile PBS.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

Specifications

• Antigen: LGMN
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q99538
• Gene Symbols: LGMN
• Immunogen: NS0-derived recombinant human Legumain/Asparaginyl Endopeptidase Ile18-Tyr433.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunoprecipitation, Western Blot
• Clone: 312114
• Conjugate: Unconjugated
• Gene: LGMN
• Gene Alias: AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 5641
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized