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Invitrogen™ LGMN Monoclonal Antibody (312114)
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Catalog No. PIMA524032
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100 μg
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PIMA524032 100 μg
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Catalog No. PIMA524032 Supplier Invitrogen™ Supplier No. MA524032
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Description

Mouse Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant mouse Legumain is observed. This antibody recognizes the pro form of human Legumain and does not recognize the mature form (aa 18-323). Reconstitute at 0.5 mg/mL in sterile PBS.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGMN
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 312114
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene LGMN
Gene Accession No. Q99538
Gene Alias AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
Gene Symbols LGMN
Host Species Mouse
Immunogen NS0-derived recombinant human Legumain/Asparaginyl Endopeptidase Ile18-Tyr433.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5641
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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