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MilliporeSigma™ LGMN, Mouse, Unlabeled, Clone: 6A7.2,

Catalog No. MABN2185MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN2185MI 100 μg Unconjugated
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Catalog No. MABN2185MI Supplier MilliporeSigma™ Supplier No. MABN2185

Description

Mouse Monoclonal Antibody

Legumain (UniProt: Q99538; EC:3.4.22.34, also known as Asparaginyl endopeptidase; Protease, cysteine 1) is encoded by LGMN (also known as PRSC1) gene (Gene ID 5641) in human. Legumain is a lysosomal enzyme with strict specificity of the hydrolysis of asparaginyl bonds. It is shown to be ubiquitously distributed with abundance in kidney, heart, and placenta. In the zymogen form, the uncleaved propeptide blocks access to the active site. It is activated autocatlytically by acidic pH and the active form is shown to be monomeric. Legumain plays a pivotal role in the endosomal/lysosomal degradation system and is involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation. Legumain deficiency causes the accumulation of pro-cathepsins B, H and L. Overexpression of legumain is associated with invasion and metastasis in a majority of solid tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGMN
Applications Western Blot
Classification Monoclonal
Clone 6A7.2
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse monoclonal antibody IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene LGMN, PRCS1
Gene Accession No. Q99538
Host Species Mouse
Immunogen GST-tagged recombinant fragment corresponding to 95 amino acids from the internal region of human LGMN.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_001008530
Test Specificity Clone 6A7.2 of detects LGMN in multiple human tissues by Western blotting and immunohistochemistry.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only. Not for use in diagnostic procedures.

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