Invitrogen™ LGMN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA581435

Catalog No. PIPA581435

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Mouse Legumain/LGMN.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

Specifications

• Antigen: LGMN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LGMN
• Gene Alias: AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 19141
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: O89017
• Gene Symbols: LGMN
• Immunogen: Recombinant Mouse Legumain/LGMN Protein (Val18-Tyr435).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov