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Invitrogen™ LGMN Polyclonal Antibody
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Catalog No. PIPA587990
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100 μL
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PIPA587990 100 μL
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Catalog No. PIPA587990 Supplier Invitrogen™ Supplier No. PA587990
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse lung, Mouse liver; Cellular Location: Lysosome.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGMN
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene LGMN
Gene Accession No. O89017, Q99538, Q9R0J8
Gene Alias AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
Gene Symbols LGMN
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19141, 5641, 63865
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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