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Invitrogen™ LGMN Recombinant Rabbit Monoclonal Antibody (6X5U6)
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Catalog No. PIMA538162
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PIMA538162 100 μL
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Catalog No. PIMA538162 Supplier Invitrogen™ Supplier No. MA538162
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: 293T, HepG2, MCF7, Mouse brain, Mouse spleen, Mouse kidney Immunogen sequence: ANPRESSYAC YYDEKRSTYL GDWYSVNWME DSDVEDLTKE TLHKQYHLVK SHTNTSHVMQ YGNKTISTMK VMQFQGMKRK ASSPVPLPPV THL.

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGMN
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 6X5U6
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene LGMN
Gene Accession No. O89017, Q99538
Gene Alias AEP; AI746452; Asparaginyl endopeptidase; AU022324; cb173; cb460; cysteine protease 1; legumain; Lgmn; LGMN1; preprolegumain; protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1; PRSC1EC 3.4.22.34; sb:cb173; wu:fa98g05; wu:fj92g08; zgc:76953
Gene Symbols LGMN
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 210-302 of human Legumain (LGMN) (Q99538).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19141, 5641
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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