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LIF Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501735446 Shop All Proteintech Group Inc Products
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50-173-5446 150 μL
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Catalog No. 50-173-5446 Supplier Proteintech Group Inc Supplier No. 267571AP150UL
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Description

Rabbit Polyclonal Antibody

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFalpha and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.

Specifications

Antigen LIF
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene LIF
Gene Accession No. P15018
Gene Alias CDF, D factor, DIA, Emfilermin, HILDA, Leukemia inhibitory factor, LIF, Melanoma derived LPL inhibitor, MLPLI
Gene Symbols LIF
Host Species Rabbit
Immunogen LIF Fusion Protein Ag25076
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3976
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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