Invitrogen™ LIGHT Monoclonal Antibody (261639)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523961

Catalog No. PIMA523961

Description

In Western blots, this antibody shows less than 10% cross-reactivity with recombinant mouse (rm) EDA, rmTRAIL, rmTRANCE, rmTWEAK, and rhVEGI but does not cross-react rm4-1BB Ligand, rhAPRIL, rmBAFF, rhEDA-A2, rmFas Ligand, rhGITR Ligand, rmGITR Ligand, rhLymphotoxin alpha 1/ beta 2, rhLymphotoxin alpha 2/ beta 2, rmOX40 Ligand, and rmTNF-alpha. Reconstitute at 0.5 mg/mL in sterile PBS.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

Specifications

• Antigen: LIGHT
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9QYH9
• Gene Symbols: TNFSF14
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse LIGHT Asp72-Val239.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 261639
• Conjugate: Unconjugated
• Gene: TNFSF14
• Gene Alias: CD258; Herpes virus entry mediator ligand; herpesvirus entry mediator ligand; HVEML; HVEM-L; Light; LTg; Ly113; sCD258; sLIGHT; soluble CD258; soluble LIGHT; Tnfsf14; TR2; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form; tumor necrosis factor superfamily member 14; UNQ391/PRO726
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 50930
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized