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Invitrogen™ LIGHT Monoclonal Antibody (C1), Invitrogen™
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Catalog No. PIMA543901
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100 μL
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Catalog No. Quantity
PIMA543901 100 μL
PIMA543902 20 μL
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Catalog No. PIMA543901 Supplier Invitrogen™ Supplier No. MA543901
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Description

Mouse Monoclonal Antibody

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIGHT
Applications Western Blot
Classification Monoclonal
Clone C1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene TNFSF14
Gene Accession No. O43557
Gene Alias CD258; Herpes virus entry mediator ligand; herpesvirus entry mediator ligand; HVEML; HVEM-L; Light; LTg; Ly113; sCD258; sLIGHT; soluble CD258; soluble LIGHT; Tnfsf14; TR2; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form; tumor necrosis factor superfamily member 14; UNQ391/PRO726
Gene Symbols TNFSF14
Host Species Mouse
Immunogen His62-Val240 (Accession O43557), with N-terminal His Tag.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 301133, 8740
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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