Invitrogen™ LIGHT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596030

Catalog No. PIPA596030

Description

Positive Samples: Raji, LO2, A-549, 293T, THP-1; Cellular Location: Cell membrane, Cytoplasm, Single-pass type II membrane protein Immunogen sequence: LQLHWRLGEM VTRLPDGPAG SWEQLIQERR SHEVNPAAHL TGANSSLTGS GGPLLWETQL GLAFLRGLSY HDGALVVTKA GYYYIYSKVQ LGGVGCPLGL ASTITHGLYK RTPRYPEE.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

Specifications

• Antigen: LIGHT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFSF14
• Gene Alias: CD258; Herpes virus entry mediator ligand; herpesvirus entry mediator ligand; HVEML; HVEM-L; Light; LTg; Ly113; sCD258; sLIGHT; soluble CD258; soluble LIGHT; Tnfsf14; TR2; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form; tumor necrosis factor superfamily member 14; UNQ391/PRO726
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 301133, 50930, 8740
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.19 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43557, Q9QYH9
• Gene Symbols: TNFSF14
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 59-176 of human TNFSF14/LIGHT (NP_0037982).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov