Invitrogen™ LILRB3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590933

Catalog No. PIPA590933

Description

Immunogen sequence: RSSNPHLLSF PSEPLELMVS GHSGGSSLPP TGPPSTPGGP EDQPLNPPGS GPQNGLGRYL EVLIGVSVAF VLLLFLLLFL LLLRQRHSKH RTSDQRKTDF Q; Positive Samples: Jurkat; Cellular Location: Cell membrane, Single-pass type I membrane protein.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: LILRB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LILRB3
• Gene Alias: CD85 antigen-like family member A; CD85A; Cell-surface glycoprotein p91; Gp91; HL9; ILT5; ILT-5; immunoglobulin-like transcript 5; leucocyte Ig-like receptor B3; leukocyte immunoglobulin like receptor B3; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; LILRA6; Lilrb3; LIR3; LIR-3; monocyte inhibitory receptor HL9; paired Ig-like receptor B; paired immunoglobulin-like receptor B; PIRB; PIR-B
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11025
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O75022
• Gene Symbols: LILRB3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human LILRB3 (NP_0013078891).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG