Invitrogen™ LILRB3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531436

Catalog No. PIPA531436

Description

Recommended positive controls: Jurkat. Predicted reactivity: Human (95%), Chimpanzee (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: LILRB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LILRB3
• Gene Alias: CD85 antigen-like family member A; CD85A; Cell-surface glycoprotein p91; Gp91; HL9; ILT5; ILT-5; immunoglobulin-like transcript 5; leucocyte Ig-like receptor B3; leukocyte immunoglobulin like receptor B3; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; LILRA6; Lilrb3; LIR3; LIR-3; monocyte inhibitory receptor HL9; paired Ig-like receptor B; paired immunoglobulin-like receptor B; PIRB; PIR-B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11025
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O75022
• Gene Symbols: LILRB3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human LILRB3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG