Invitrogen™ LILRB4 Polyclonal Antibody

Catalog No.	Quantity
PIPA547314	100 μg

Catalog No. PIPA547314 Supplier Invitrogen™ Supplier No. PA547314

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately10% cross-reactivity with recombinant human (rh) ILT4 and rhILT5 is observed, and less than 5% cross-reactivity with recombinant human ILT2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: LILRB4
• Applications: Flow Cytometry, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: LILRB4
• Gene Accession No.: Q8NHJ6
• Gene Alias: CD85 antigen-like family member K; CD85K; glycoprotein 49 B; glycoprotein 49b; gp49; Gp49b; GP49B2; HM18; ILT3; ILT-3; Immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin like receptor B4; leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte surface receptor; Lilrb4; LIR5; LIR-5; mast cell surface glycoprotein Gp49B; Monocyte inhibitory receptor HM18
• Gene Symbols: LILRB4
• Host Species: Goat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LILRB4/CD85k/ILT3 Pro17-His257.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11006
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG