LIME1 Monoclonal Antibody (OTI3B10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA807653

Catalog No. 50-168-1673

Description

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.

Specifications

• Antigen: LIME1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9H400
• Gene Symbols: LIME1
• Immunogen: Human recombit protein fragment corresponding to amino acids 30-295 of human LIME1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3B10
• Conjugate: Unconjugated
• Gene: LIME1
• Gene Alias: LIME, dJ583P15.4
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54923
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid