LIME1 Mouse anti-Human, Clone: OTI7A9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807654

Catalog No. 50-166-8395

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.

Specifications

• Antigen: LIME1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: LIME1
• Gene Alias: LIME, dJ583P15.4
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54923
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI7A9
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9H400
• Gene Symbols: LIME1
• Immunogen: Human recombit protein fragment corresponding to amino acids 30-295 of human LIME1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1