Invitrogen™ LIMK1 Monoclonal Antibody (175CT3.2.5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA537486

Catalog No. PIMA537486

Description

LIMK1 Monoclonal Antibody for Western Blot

LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK1 has also been implicated in brain development. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.

Specifications

• Antigen: LIMK1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: LIMK1
• Gene Alias: EC 2.7.11.1; kinase LIMK1; KIZ-1; LIM domain kinase 1; lim kinase 1; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK1; LIMK-1
• Host Species: Mouse
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 16885, 3984
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Clone: 175CT3.2.5
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P53667, P53668
• Gene Symbols: LIMK1
• Immunogen: KLH conjugated synthetic peptide between 479-508 amino acids from the C-terminal region of human LIMK1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgM κ