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Invitrogen™ LIMK1 Polyclonal Antibody
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Catalog No. PIPA583017
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100 μL
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Catalog No. Quantity
PIPA583017 100 μL
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Catalog No. PIPA583017 Supplier Invitrogen™ Supplier No. PA583017
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EHSKLYCGHC YYQTVVTPVI EQILPDSPGS HLPHTVTLVS IPASSHGKRG LSVSIDPPHG PPGCGTEHSH TVRVQGVDPG CMSPDVKNSI HV Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 98%.

LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK1 has also been implicated in brain development. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIMK1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LIMK1
Gene Accession No. P53667
Gene Alias EC 2.7.11.1; kinase LIMK1; KIZ-1; LIM domain kinase 1; lim kinase 1; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK1; LIMK-1
Gene Symbols LIMK1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LIMK1. Recombinant protein control fragment (Product #RP-95198).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3984
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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