Invitrogen™ LIMK2 Monoclonal Antibody (T.756.1)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA515136

Catalog No. PIMA515136

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with LIMK1.

LIMK2 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK2 has also been implicated in brain development. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for LIMK2.

Specifications

• Antigen: LIMK2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: LIMK2
• Gene Alias: EC 2.7.11.1; kinase LIMK2; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIMK; LIMK 2; LIMK1; LIMK-1; Limk2; LIMK-2; Limk2b; LINhp-2; Link2; OTTHUMP00000199483
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3985
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Clone: T.756.1
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
• Gene Accession No.: P53671
• Gene Symbols: LIMK2
• Immunogen: Synthetic peptide corresponding to carboxy-terminal residues of human LIMK2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Monkey
• Product Type: Antibody
• Isotype: IgG