Invitrogen™ LIMK2 Monoclonal Antibody (T.756.1)

Catalog No.	Quantity
PIMA515136	100 μL

Catalog No. PIMA515136 Supplier Invitrogen™ Supplier No. MA515136

Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with LIMK1.

LIMK2 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK2 has also been implicated in brain development. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for LIMK2.

Specifications

• Antigen: LIMK2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: T.756.1
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
• Gene: LIMK2
• Gene Accession No.: P53671
• Gene Alias: EC 2.7.11.1; kinase LIMK2; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIMK; LIMK 2; LIMK1; LIMK-1; Limk2; LIMK-2; Limk2b; LINhp-2; Link2; OTTHUMP00000199483
• Gene Symbols: LIMK2
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to carboxy-terminal residues of human LIMK2.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3985
• Target Species: Human, Monkey
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG