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Invitrogen™ LIN28A Monoclonal Antibody (14E6-4E6), DyLight™ 488
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Catalog No. MA1016D488
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MA1016D488 100 μL
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Catalog No. MA1016D488 Supplier Invitrogen™ Supplier No. MA1016D488
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Description

Mouse Monoclonal Antibody

MA1-016-D488 has been successfully used in ICC/IF and flow cytometry applications on human and mouse samples. MA1-016-D488 can be used for immunofluorescence analysis of LIN28 in human iPSCs.

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIN28A
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 14E6-4E6
Concentration 1 mg/mL
Conjugate DyLight 488
Formulation PBS with proprietary stabilizer and 0.02% sodium azide
Gene LIN28A
Gene Accession No. Q8K3Y3, Q9H9Z2
Gene Alias AL024421; CSDD1; ENSMUSG00000070700; FLJ12457; Gm10299; Lin28; LIN-28; lin-28 homolog A; lin-28 homolog A (C. elegans); Lin28a; lin-28A; Protein lin-28 homolog A; RGD1566408; RNA-binding protein LIN-28; sb:cb650; si:ch211-232d9.4; similar to RNA-binding protein LIN-28; testis expressed gene 17; testis-expressed protein 17; Tex17; ZCCHC1; zgc:55584; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Gene Symbols LIN28A
Host Species Mouse
Immunogen Full-length human recombinant protein expressed in bacteria.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79727, 83557
Target Species Human, Mouse
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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