LIN28A Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Supplier:  Active Motif 61192

Catalog No. 50-199-3221

Description

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Specifications

• Antigen: LIN28A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LIN28A
• Gene Alias: AL024421; CSDD1; ENSMUSG00000070700; FLJ12457; Gm10299; lin28; lin-28; lin-28 homolog A; lin-28 homolog A (C. elegans); Lin28a; Lin-28A; Protein lin-28 homolog A; RGD1566408; RNA-binding protein lin-28; sb:cb650; si:ch211-232d9.4; similar to RNA-binding protein LIN-28; testis expressed gene 17; Testis-expressed protein 17; Tex17; ZCCHC1; zgc:55584; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79727, 83557
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Concentration: Lot-Specific
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: Q8K3Y3, Q9H9Z2
• Gene Symbols: LIN28A
• Immunogen: This LIN28A antibody was raised against a peptide derived from the C-terminal region of human LIN28A.
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG