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Invitrogen™ LIN28A Recombinant Rabbit Monoclonal Antibody (2S1I10)
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Catalog No. PIMA542929
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PIMA542929 100 μL
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Catalog No. PIMA542929 Supplier Invitrogen™ Supplier No. MA542929
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: Mouse testis, Rat testis. Immunogen sequence: MGSVSNQQFA GGCAKAAEEA PEEAPEDAAR AADEPQLLHG AGICKWFNVR MGFGFLSMTA RAGVALDPPV DVFVHQSKLH MEGFRSLKEG EAVEFTFKKS.

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIN28A
Applications ELISA, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Recombinant Monoclonal
Clone 2S1I10
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene LIN28A
Gene Accession No. Q8K3Y3, Q9H9Z2
Gene Alias AL024421; CSDD1; ENSMUSG00000070700; FLJ12457; Gm10299; Lin28; LIN-28; lin-28 homolog A; lin-28 homolog A (C. elegans); Lin28a; lin-28A; Protein lin-28 homolog A; RGD1566408; RNA-binding protein LIN-28; sb:cb650; si:ch211-232d9.4; similar to RNA-binding protein LIN-28; testis expressed gene 17; testis-expressed protein 17; Tex17; ZCCHC1; zgc:55584; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Gene Symbols LIN28A
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LIN28A (Q9H9Z2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 500562, 79727, 83557
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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