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Invitrogen™ LIN7B Polyclonal Antibody
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Catalog No. PIPA5142088
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100 μg
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PIPA5142088 100 μg
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Catalog No. PIPA5142088 Supplier Invitrogen™ Supplier No. PA5142088
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Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LIN7B
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene LIN7B
Gene Accession No. O88951, Q9Z252
Gene Alias hLin7B; hVeli2; lin 7 homolog b; lin-7 homolog B; lin-7 homolog B (C. elegans); lin-7 homolog B, crumbs cell polarity complex component; lin-7-A; LIN7B; lin-7B; MALS2; MALS-2; Mammalian lin-seven protein 2; protein lin-7 homolog B; UNQ3116/PRO10200; Veli1a; Veli2; Veli-2; veli-2 protein; vertebrate homolog of C. elegans Lin-7 type 2; vertebrate lin-7 homolog 2
Gene Symbols LIN7B
Host Species Goat
Immunogen Peptide with sequence AALVEPLGLERDVS-C (aa 2-15).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22342, 60377
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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