Invitrogen™ LINGO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597210

Catalog No. PIPA597210

Description

Immunogen sequence: CPPRCECSAQ DRAVLCHRKR FVAVPEGIPT ETRLLDLGKN RIKTLNQDEF ASFPHLEELE LNENIVSAVE PGAFNNLFNL RTLGLRSNRL KLIPLGVFTG LSNLTKLDIS ENKIVILLDY MFQDLYNLKS LEVGDNDLVY ISHRAFSGLN SLEQLTLEKC NLTSIPTEAL SHLHGLIVLR LRHLNINAIR DYSFKRLYR; Positive Samples: MCF-7, A-549, K-562, Mouse testis, Mouse lung; Cellular Location: Cell membrane, Single-pass type I membrane protein.

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. [UniProt].

Specifications

• Antigen: LINGO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LINGO1
• Gene Alias: 4930471K13Rik; AV148400; LERN1; leucine rich repeat and Ig domain containing 1; leucine rich repeat neuronal 6A; leucine-rich repeat; leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine-rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A; Lingo1; LINGO-1; LRRN6A; UNQ201; UNQ201/PRO227
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 235402, 84894
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96FE5, Q9D1T0
• Gene Symbols: LINGO1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-240 of human LINGO1 (NP_1161974).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG