Invitrogen™ LINGO2 Polyclonal Antibody

Catalog No.	Quantity
PIPA570765	100 μL

Catalog No. PIPA570765 Supplier Invitrogen™ Supplier No. PA570765

Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 86%.

Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 (LINGO2) is a gene located on chromosome 9q34.3, encoding a transmembrane protein predominantly expressed in the central nervous system. Structurally, LINGO2 features leucine-rich repeat (LRR) domains and immunoglobulin-like domains, which are crucial for molecular interactions and signaling. Functionally, LINGO2 is involved in regulating neural growth and development, influencing processes such as axon guidance and synaptic plasticity. It modulates neurotransmitter receptor activity and intracellular signaling pathways essential for neural transmission, with implications for both normal cognitive function and neurological disorders. Altered expression of LINGO2 has been associated with movement disorders, as well as neurodegenerative conditions, suggesting its role in neural circuit integrity. Current research on LINGO2 is exploring its potential as a therapeutic target for enhancing neural repair mechanisms and addressing synaptic dysfunction, providing insights into interventions for neurological diseases.

Specifications

• Antigen: LINGO2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: LINGO2
• Gene Accession No.: Q3URE9
• Gene Alias: B230217C06Rik; LERN3; LERN3FLJ31810; leucine rich repeat and Ig domain containing 2; leucine rich repeat neuronal 6C; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine-rich repeat neuronal protein 3; leucine-rich repeat neuronal protein 6C; Lingo2; LRRN6C; RGD1310773; UNQ9234/PRO31993
• Gene Symbols: LINGO2
• Host Species: Rabbit
• Immunogen: synthetic peptide directed towards the C-terminal region of mouse LINGO2.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 242384
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG