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Invitrogen™ LINGO2 Polyclonal Antibody
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Catalog No. PIPA599869
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PIPA599869 100 μL
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Catalog No. PIPA599869 Supplier Invitrogen™ Supplier No. PA599869
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total LINGO2.

Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 (LINGO2) is a gene located on chromosome 9q34.3, encoding a transmembrane protein predominantly expressed in the central nervous system. Structurally, LINGO2 features leucine-rich repeat (LRR) domains and immunoglobulin-like domains, which are crucial for molecular interactions and signaling. Functionally, LINGO2 is involved in regulating neural growth and development, influencing processes such as axon guidance and synaptic plasticity. It modulates neurotransmitter receptor activity and intracellular signaling pathways essential for neural transmission, with implications for both normal cognitive function and neurological disorders. Altered expression of LINGO2 has been associated with movement disorders, as well as neurodegenerative conditions, suggesting its role in neural circuit integrity. Current research on LINGO2 is exploring its potential as a therapeutic target for enhancing neural repair mechanisms and addressing synaptic dysfunction, providing insights into interventions for neurological diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LINGO2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LINGO2
Gene Accession No. Q3URE9, Q7L985
Gene Alias B230217C06Rik; LERN3; LERN3FLJ31810; leucine rich repeat and Ig domain containing 2; leucine rich repeat neuronal 6C; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine-rich repeat neuronal protein 3; leucine-rich repeat neuronal protein 6C; Lingo2; LRRN6C; RGD1310773; UNQ9234/PRO31993
Gene Symbols LINGO2
Host Species Rabbit
Immunogen A synthesized peptide derived from human LINGO2(Accession Q7L985), corresponding to amino acid residues L364-E414.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 158038, 242384, 313156
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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