Invitrogen™ Livin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA594927

Catalog No. PIPA594927

Description

Human Livin shares 69.8% amino acid (aa) sequence identity with mouse Livin. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: HELA whole cell, A431 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, it has been identified that a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.

Specifications

• Antigen: Livin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BIRC7
• Gene Alias: baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing 7; baculoviral IAP repeat-containing 7 (livin); baculoviral IAP repeat-containing protein 7; Baculoviral IAP repeat-containing protein 7 30 kDa subunit; Baculoviral IAP repeat-containing protein 7 30kDa subunit; Birc7; E130019N06; KIAP; Kidney inhibitor of apoptosis protein; LIVIN; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; MLIAP; ML-IAP; RGD1562883; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; RNF50; RP11-261N11.7; Truncated livin; UNQ5800/PRO19607/PRO21344
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79444
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: Q96CA5
• Gene Symbols: BIRC7
• Immunogen: E.coli-derived human Livin recombinant protein (Position: E87-S298).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov