Invitrogen™ LKB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596062

Catalog No. PIPA596062

Description

Immunogen sequence: CGMQEMLDSV PEKRFPVCQA HGYFCQLIDG LEYLHSQGIV HKDIKPGNLL LTTGGTLKIS DLGVAEALHP FAADDTCRTS QGSPAFQPPE IANGLDTFSG FKVDIWSAGV TLYNITTGLY PFEGDNIYKL FENIGKGSYA IPGDCGPPLS DLLKGMLEYE PAKRFSIRQI RQHSWFRKKH PPAEAPVPIP PSPDTKDRWR SMTVVPYLED LHGADEDEDL FDIEDDIIYT QDFTVPGQVP EEEASHNGQR RGLPKAVCMN GTEAAQLSTK SRAEGRAPNP ARKACSASSK IRRLSACKQQ; Positive Samples: U-87MG, SKOV3, Mouse heart; Cellular Location: Cytoplasm, Membrane, Mitochondrion, Nucleus.

LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.

Specifications

• Antigen: LKB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STK11
• Gene Alias: AA408040; CAMK group; CAMKL family; hLKB1; liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB1; LKB-1; LKB1(S); Par-4; PJS; polarization-related protein LKB1; R75140; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11; STK11
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20869, 314621, 6794
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.75 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: D4AE59, Q15831, Q9WTK7
• Gene Symbols: STK11
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human LKB1 (NP_0004461).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG