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Invitrogen™ LKB1 Polyclonal Antibody
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Catalog No. PIPA596062
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100 μL
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PIPA596062 100 μL
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Catalog No. PIPA596062 Supplier Invitrogen™ Supplier No. PA596062
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CGMQEMLDSV PEKRFPVCQA HGYFCQLIDG LEYLHSQGIV HKDIKPGNLL LTTGGTLKIS DLGVAEALHP FAADDTCRTS QGSPAFQPPE IANGLDTFSG FKVDIWSAGV TLYNITTGLY PFEGDNIYKL FENIGKGSYA IPGDCGPPLS DLLKGMLEYE PAKRFSIRQI RQHSWFRKKH PPAEAPVPIP PSPDTKDRWR SMTVVPYLED LHGADEDEDL FDIEDDIIYT QDFTVPGQVP EEEASHNGQR RGLPKAVCMN GTEAAQLSTK SRAEGRAPNP ARKACSASSK IRRLSACKQQ; Positive Samples: U-87MG, SKOV3, Mouse heart; Cellular Location: Cytoplasm, Membrane, Mitochondrion, Nucleus.

LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LKB1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene STK11
Gene Accession No. D4AE59, Q15831, Q9WTK7
Gene Alias AA408040; CAMK group; CAMKL family; hLKB1; liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB1; LKB-1; LKB1(S); Par-4; PJS; polarization-related protein LKB1; R75140; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11; STK11
Gene Symbols STK11
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human LKB1 (NP_0004461).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20869, 314621, 6794
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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