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  5. Tocris Bioscience™ LM11A 31 dihydrochloride

Tocris Bioscience™ LM11A 31 dihydrochloride

Catalog No. 504610R
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50-461-0R 10 mg
50-465-0R 50 mg
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Catalog No. 50-461-0R Supplier Tocris Bioscience™ Supplier No. 5046/10
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Description

Nonpeptide p75NTR ligand; neuroprotective

LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC50 = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC50 = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

Specifications

Purity 95%
Molecular Formula (2 S,3 S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
CAS 1243259-19-9
Content And Storage Desiccate at RT
Quantity 10 mg
Product Type LM11A 31 dihydrochloride
Molecular Weight (g/mol) M.W. (Observed): 316.27
Inhibitors LM11A 31 dihydrochloride

For Research Use Only

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