Invitrogen™ LMAN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1074

Catalog No. PA1074

Description

PA1-074 detects ERGIC-53 in rat, mouse and human samples. PA1-074 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a ~57.5 kDa protein representing ERGIC-53 in rat brain samples. The PA1-074 immunogen is a synthetic peptide corresponding to residues F(159) D S F D N D G K K N N P A I(173) of rat ERGIC-53. This sequence is conserved in mouse and human. The PA1-074 immunizing peptide (Cat. # PEP-277) is available for use in neutralization and control experiments.

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Specifications

• Antigen: LMAN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LMAN1
• Gene Alias: 2610020P13Rik; AI326273; AU043785; C730041J05; EGK_09725; endoplasmic reticulum-golgi intermediate compartment protein 53; ERGIC53; ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; F5F8D; FMFD1; Gp58; intracellular mannose-specific lectin MR60; Lectin mannose-binding 1; lectin, mannose binding 1; lectin, mannose-binding, 1; LMAN1; MCFD1; MR60; P58; Protein ERGIC-53
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116666, 3998, 70361
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P49257, Q62902, Q9D0F3
• Gene Symbols: LMAN1
• Immunogen: Synthetic peptide corresponding to residues F(159) D S F D N D G K K N N P A I(173) of rat ERGIC-53.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG