Invitrogen™ LNX2 Polyclonal Antibody

Catalog No.	Quantity
PIPA546740	100 μL

Catalog No. PIPA546740 Supplier Invitrogen™ Supplier No. PA546740

Description

Rabbit Polyclonal Antibody

Peptide sequence: LRERRFGNRA HNHSDSNSPR EEIFQVALHK RDSGEQLGIK LVRRTDEPGV.

LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.

Specifications

• Antigen: LNX2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: LNX2
• Gene Accession No.: Q8N448
• Gene Alias: 9630046H24; AW209022; ligand of Numb protein X 2; ligand of numb-protein X 2; Lnx2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain-containing RING finger protein 1; PDZRN1
• Gene Symbols: LNX2
• Host Species: Rabbit
• Immunogen: Synthetic peptide directed towards the middle region of human LNX2.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 222484
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG