Invitrogen™ LNX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA546740

Catalog No. PIPA546740

Description

Peptide sequence: LRERRFGNRA HNHSDSNSPR EEIFQVALHK RDSGEQLGIK LVRRTDEPGV.

LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.

Specifications

• Antigen: LNX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LNX2
• Gene Alias: 9630046H24; AW209022; ligand of Numb protein X 2; ligand of numb-protein X 2; Lnx2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain-containing RING finger protein 1; PDZRN1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 222484
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8N448
• Gene Symbols: LNX2
• Immunogen: Synthetic peptide directed towards the middle region of human LNX2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG