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Invitrogen™ LNX2 Polyclonal Antibody

Catalog No. PI720004
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100 μg
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Catalog No. Quantity
PI720004 100 μg
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Catalog No. PI720004 Supplier Invitrogen™ Supplier No. 720004

Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with Goat, Bovine, Horse, Pig, Cat and Rabbit.

LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LNX2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.2
Gene LNX2
Gene Accession No. Q8N448, Q91XL2
Gene Alias 9630046H24; AW209022; ligand of Numb protein X 2; ligand of numb-protein X 2; Lnx2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain-containing RING finger protein 1; PDZRN1
Gene Symbols LNX2
Host Species Rabbit
Immunogen Multiple peptides against Human LNX2 (aa 442-458, 129-145, 671-683).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140887, 222484, 360761
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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