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  5. Tocris Bioscience™ Lomeguatrib

Tocris Bioscience™ Lomeguatrib
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Catalog No. 435910
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

MGMT inhibitor

Lomeguatrib (LomG) is a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells); LomG attenuates MGMT activity in vitro and in vivo. LomG enhances the antitumor activity of temozolomide (Cat. No. 2706) in both human melanoma and MCF-7 xenografts. LomG acts as a pseudosubstrate for MGMT and can be used to induce rapid ubiquitin proteasome pathway degradation of proteins that have a MGMT fusion.

Chemical Identifiers

CAS 192441-08-0
Molecular Formula C10H8BrN5OS

Specifications

Quantity 10 mg
Formula Weight 326.17
Purity >98%
Molecular Weight (g/mol) 326.17
Chemical Name or Material Lomeguatrib

Safety and Handling

Recommended Storage Store at +4°C
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