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Invitrogen™ LON Polyclonal Antibody
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Catalog No. PIPA580261
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100 μL
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PIPA580261 100 μL
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Catalog No. PIPA580261 Supplier Invitrogen™ Supplier No. PA580261
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Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Escherichia coli LON PROTEASE.

Lon protease is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Lon protease degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. It binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, UmuD and at least type II antitoxins CcdA, HipB and MazE. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system. Overproduction leads to very high persister cell formation (cells highly resistant to antibiotics), but not when 10 mRNA interferases are deleted, nor when Lon catalytic residues are mutated.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LON
Applications ELISA
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Alias ATP-dependent protease La; capR; muc
Host Species Rabbit
Immunogen Recombinant Escherichia coli LON PROTEASE protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Bacteria
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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