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Invitrogen™ LOX-1 Monoclonal Antibody (23C11), FITC
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Catalog No. FERMA549085
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100 μg
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Catalog No. Quantity
FERMA549085 100 μg
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Catalog No. FERMA549085 Supplier Invitrogen™ Supplier No. MA549085
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Description

Mouse Monoclonal Antibody

Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.

LOX-1 (lectin-like oxidized LDL receptor -1) is a 40-50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged /apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LOX-1
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone 23C11
Concentration 100 μg/mL
Conjugate FITC
Formulation PBS with 1% BSA and 0.02% sodium azide
Gene OLR1
Gene Accession No. P78380
Gene Alias CLEC8A; C-type lectin domain family 8 member A; hLOX 1; hLOX1; hLOX-1; lectin-like oxidized LDL receptor; lectin-like oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; Lectin-like oxidized low-density lipoprotein receptor-1; lectin-like oxLDL receptor 1; lectin-type oxidized LDL receptor 1; LOX 1; LOX1; LOX-1; LOXIN; Oldlr1; Oldr1; OLR1; ox LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein receptor 1; oxidized low-density lipoprotein receptor 1; Oxidized low-density lipoprotein receptor 1, soluble form; ox-LDL receptor 1; Scare1; scavenger receptor class E, member 1; sLOX 1; SLOX1; soluble LOX 1; SR-EI
Gene Symbols OLR1
Host Species Mouse
Immunogen Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fc-gamma1 (LOX-1-muFc) produced in PEAK cells.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4973
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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