LOXL2 Mouse anti-Human, Clone: OTI2A7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807441

Catalog No. 50-166-8273

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Lysyl Oxidase (LO) is an extracellular, copper-dependent enzyme that initiates the cross-linking of collagens and elastin by catalyzing the oxidative deamination of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde. Members of LO family have diverse functions which include tumor suppression and cell adhesion and senescence. LOXL2, a 87KDa protein, is a novel member of this family. It contains 3 potential N-linked glycosylation sites, 4 scavenger receptor cysteine-rich (SRCR) domains and highly conserved copper-binding and Lysyl-tyrosylquinone cofactor sites. It is a component of extracellular matrix that might be involved in cell adhesion and senescence. Role of LOXL2 has been implicated in maligt transformation.

Specifications

• Antigen: LOXL2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: LOXL2
• Gene Alias: LOR, LOR2, WS9-14
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4017
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2A7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9Y4K0
• Gene Symbols: LOXL2
• Immunogen: Human recombit protein fragment corresponding to amino acids 152-450 of human LOXL2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1