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Invitrogen™ LPHN1 Polyclonal Antibody
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Catalog No. PIPA533903
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50 μg
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PIPA533903 50 μg
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Catalog No. PIPA533903 Supplier Invitrogen™ Supplier No. PA533903
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Description

Rabbit Polyclonal Antibody

LPHN1 Polyclonal Antibody for IHC (P)

Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis. The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1. Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LPHN1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.74 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene Adgrl1
Gene Accession No. O88917, O94910, O97831, Q80TR1
Gene Alias 2900070I05Rik; ADGRL1; Adhesion G protein-coupled receptor L1; AI182398; calcium-independent alpha-latrotoxin receptor 1; Cirl; Cirl1; CIRL-1; CL1; CL1BA; CLIBA; KIAA0821; latrophilin 1; latrophilin-1; LEC2; Lectomedin-2; Lphh2; LPHN1; mKIAA0821
Gene Symbols Adgrl1
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN1.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100359196, 100514215, 100760780, 22859, 330814, 610349, 65096, 788252
Target Species Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Bat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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