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Invitrogen™ LPHN1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA533903
Description
LPHN1 Polyclonal Antibody for IHC (P)
Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis. The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1. Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
Specifications
LPHN1 | |
Polyclonal | |
Unconjugated | |
Adgrl1 | |
2900070I05Rik; ADGRL1; Adhesion G protein-coupled receptor L1; AI182398; calcium-independent alpha-latrotoxin receptor 1; Cirl; Cirl1; CIRL-1; CL1; CL1BA; CLIBA; KIAA0821; latrophilin 1; latrophilin-1; LEC2; Lectomedin-2; Lphh2; LPHN1; mKIAA0821 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
100359196, 100514215, 100760780, 22859, 330814, 610349, 65096, 788252 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.74 mg/mL | |
PBS with 0.1% sodium azide | |
O88917, O94910, O97831, Q80TR1 | |
Adgrl1 | |
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN1. | |
50 μg | |
Primary | |
Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Bat | |
Antibody | |
IgG |
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