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Invitrogen™ LPHN1 Polyclonal Antibody
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Catalog No. PIPA558189
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100 μL
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PIPA558189 100 μL
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Catalog No. PIPA558189 Supplier Invitrogen™ Supplier No. PA558189
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GNHLLTNPVL QPRGGTSPYN TLIAESVGFN PSSPPVFNSP GSYREPKHPL GGREACGMDT LP Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis. The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1. Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LPHN1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Adgrl1
Gene Accession No. O94910
Gene Alias 2900070I05Rik; ADGRL1; Adhesion G protein-coupled receptor L1; AI182398; calcium-independent alpha-latrotoxin receptor 1; Cirl; Cirl1; CIRL-1; CL1; CL1BA; CLIBA; KIAA0821; latrophilin 1; latrophilin-1; LEC2; Lectomedin-2; Lphh2; LPHN1; mKIAA0821
Gene Symbols Adgrl1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LPHN1. Recombinant protein control fragment (Product #RP-95303).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22859
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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