Invitrogen™ LPIN1 Monoclonal Antibody (OTI8F10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526769

Catalog No. PIMA526769

Description

LPIN1 Monoclonal Antibody for Western Blot, IHC (P)

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Specifications

• Antigen: LPIN1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q14693
• Gene Symbols: LPIN1
• Immunogen: Full length human recombinant protein of LPIN1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI8F10
• Conjugate: Unconjugated
• Gene: LPIN1
• Gene Alias: 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; lipin-1; LPIN1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23175
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid