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Invitrogen™ LPIN1 Polyclonal Antibody
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Catalog No. PIPA116998
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100 μL
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PIPA116998 100 μL
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Catalog No. PIPA116998 Supplier Invitrogen™ Supplier No. PA116998
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Description

Rabbit Polyclonal Antibody

Suggested positive control: 3T3-L1 cell lysates, antigen standard for LPIN1 (transient overexpression lysate). Immunogen sequence homology: primate (94%) and rat (76%) protein.

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LPIN1
Applications Western Blot
Classification Polyclonal
Concentration 1.08 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.1% sodium azide
Gene LPIN1
Gene Accession No. Q14693, Q91ZP3
Gene Alias 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; lipin-1; LPIN1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
Gene Symbols LPIN1
Host Species Rabbit
Immunogen A synthetic peptide to an internal region (within residues 500-600) of the human LPIN1 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14245, 23175
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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