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Invitrogen™ LPIN1 Polyclonal Antibody
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Catalog No. PIPA530461
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100 μL
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PIPA530461 100 μL
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Catalog No. PIPA530461 Supplier Invitrogen™ Supplier No. PA530461
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Jurkat, NCI-H929, mouse brown, white adipose. Predicted reactivity: Mouse (91%), Rat (86%), Pig (90%), Sheep (87%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LPIN1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene LPIN1
Gene Accession No. Q14693, Q91ZP3
Gene Alias 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; lipin-1; LPIN1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
Gene Symbols LPIN1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Lipin 1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14245, 23175
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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