Lpin1 protein Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0490	100 μL

Catalog No. 50-198-0490 Supplier Bioss Supplier No. BS0759R

Description

Rabbit Polyclonal Antibody

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Specifications

• Antigen: Lpin1 protein
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: LPIN1
• Gene Accession No.: Q14693
• Gene Alias: 4631420P06; DKFZp781P1796; Fatty liver dystrophy protein; Fld; KIAA0188; lipin 1; Lipin1; Lipin-1; Lpin1; mKIAA0188; PAP1; Phosphatidate phosphatase LPIN1
• Gene Symbols: LPIN1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from mouse Lpin1 protein.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23175
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG