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Invitrogen™ LPIN3 Polyclonal Antibody
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Catalog No. PIPA562663
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100 μL
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PIPA562663 100 μL
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Catalog No. PIPA562663 Supplier Invitrogen™ Supplier No. PA562663
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FFVQELESDD EHVPPGLCTS PIPWGGLSGF PSDSQLGTAS EPEGLVMAGT ASTGRRKRRR RRKPKQKEDA VATDSSP Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 75%.

Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes and three human homologs. Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LPIN3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LPIN3
Gene Accession No. Q9BQK8
Gene Alias 9130206L11Rik; AA438110; AV236139; dJ450M14.2; dJ450M14.3; dJ620E11.2; lipin 3; lipin 3-like; lipin-3; Lipin-3-like; LIPN3L; Lpin3; mKIAA4023; Phosphatidate phosphatase LPIN3; RP4-620E11.3; SMP2
Gene Symbols LPIN3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LPIN3. Recombinant protein control fragment (Product #RP-99435).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64900
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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