Invitrogen™ LPIN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562663

Catalog No. PIPA562663

Description

Immunogen sequence: FFVQELESDD EHVPPGLCTS PIPWGGLSGF PSDSQLGTAS EPEGLVMAGT ASTGRRKRRR RRKPKQKEDA VATDSSP Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 75%.

Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes and three human homologs. Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.

Specifications

• Antigen: LPIN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LPIN3
• Gene Alias: 9130206L11Rik; AA438110; AV236139; dJ450M14.2; dJ450M14.3; dJ620E11.2; lipin 3; lipin 3-like; lipin-3; Lipin-3-like; LIPN3L; Lpin3; mKIAA4023; Phosphatidate phosphatase LPIN3; RP4-620E11.3; SMP2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64900
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BQK8
• Gene Symbols: LPIN3
• Immunogen: Recombinant protein corresponding to Human LPIN3. Recombinant protein control fragment (Product #RP-99435).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov