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Invitrogen™ LRGUK Polyclonal Antibody
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Catalog No. PIPA529413
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100 μL
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Catalog No. Quantity
PIPA529413 100 μL
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Catalog No. PIPA529413 Supplier Invitrogen™ Supplier No. PA529413
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Huh7, mouse testis, rat testis. Predicted reactivity: Mouse (88%), Rat (89%), Bovine (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The LRGUK (Leucine-Rich Repeat and Guanylate Kinase-Like Domain Containing 1) gene encodes a protein that plays a critical role in male fertility. It is particularly important for the proper function of the manchette, a microtubule-based structure involved in sperm head shaping and tail formation during spermiogenesis. Research has shown that LRGUK1 is part of a multiprotein complex essential for the initiation of sperm tail growth from the centriole/basal body. Mutations or disruptions in the LRGUK1 gene can lead to defective manchette function, resulting in abnormal sperm morphology and infertility. This gene's role in spermatogenesis underscores its importance in reproductive health, with ongoing studies aimed at elucidating its specific interactions and mechanisms within the manchette complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRGUK
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene LRGUK
Gene Accession No. Q96M69, Q9D5S7
Gene Alias 4921528H16Rik; CFAP246; leucine rich repeats and guanylate kinase domain containing; leucine-rich repeat and guanylate kinase domain-containing protein; leucine-rich repeats and guanylate kinase domain containing; Lrguk; RGD1308226
Gene Symbols LRGUK
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human FLJ32786. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 136332, 296968, 74354
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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