Invitrogen™ LRP12 Isoform A Precursor Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104431

Catalog No. PIPA5104431

Description

Antibody detects endogenous levels of total LRP12.

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP12, also designated ST7, is a member of the LDLR family that is thought to be involved in the internalization of lipophilic molecules and/or signal transduction. LRP12 has been shown to interact with RACK1, MADHIP and Integrin beta-1-binding protein 3. It is widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. Overexpression of LRP12 may be associated with oral tumors, therefore implicating LRP12 as a potential oncogene.

Specifications

• Antigen: LRP12 Isoform A Precursor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRP12
• Gene Alias: LDL receptor related protein 12; LDLR-related protein 12; low density lipoprotein receptor-related protein 12; low-density lipoprotein receptor-related protein 12; LRP12; ST7; Suppressor of tumorigenicity 7 protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29967
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9Y561
• Gene Symbols: LRP12
• Immunogen: A synthesized peptide derived from human LRP12(Accession Q9Y561), corresponding to amino acid residues T408-C458.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov