Invitrogen™ LRP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550233

Catalog No. PA550233

Description

The antibody detects endogenous levels of total LRP12 protein.

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP12, also designated ST7, is a member of the LDLR family that is thought to be involved in the internalization of lipophilic molecules and/or signal transduction. LRP12 has been shown to interact with RACK1, MADHIP and Integrin beta-1-binding protein 3. It is widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. Overexpression of LRP12 may be associated with oral tumors, therefore implicating LRP12 as a potential oncogene.

Specifications

• Antigen: LRP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LRP12
• Gene Alias: AI848829; C820005L12Rik; LDL receptor related protein 12; LDLR-related protein 12; low density lipoprotein receptor-related protein 12; low density lipoprotein-related protein 12; low-density lipoprotein receptor-related protein 12; LRP12; LRP-12; ST7; Suppressor of tumorigenicity 7 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29967
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9Y561
• Gene Symbols: LRP12
• Immunogen: Fusion protein corresponding to a region derived from internal residues of human low density lipoprotein receptor-related protein 12.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG