Lrp2/Megalin Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-5744	100 μL

Catalog No. 50-198-5744 Supplier Bioss Supplier No. BS3909R

Description

Rabbit Polyclonal Antibody

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Specifications

• Antigen: Lrp2/Megalin
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Lrp2
• Gene Accession No.: P98164
• Gene Alias: AI315343; AW536255; b2b1625.2Clo; calcium sensor protein; D230004K18Rik; DBS; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; LDL receptor related protein 2; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; Low-density lipoprotein receptor-related protein 2; Lrp2; LRP-2; Megalin
• Gene Symbols: Lrp2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Megalin.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4036
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG