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Invitrogen™ LRP2 Polyclonal Antibody
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Catalog No. PA550516
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100 μL
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PA550516 100 μL
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Catalog No. PA550516 Supplier Invitrogen™ Supplier No. PA550516
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total LRP2 protein.

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRP2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Lrp2
Gene Accession No. P98164
Gene Alias AI315343; AW536255; b2b1625.2Clo; calcium sensor protein; D230004K18Rik; DBS; Glycoprotein 330; Gp330; Heymann nephritis antigen homolog; LDL receptor related protein 2; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; Lrp2; LRP-2; Megalin
Gene Symbols Lrp2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to a region derived from internal residues of human low density lipoprotein receptor-related protein 2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4036
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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