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Invitrogen™ LRP2 Polyclonal Antibody
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Catalog No. PIPA576470
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100 μL
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PIPA576470 100 μL
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Catalog No. PIPA576470 Supplier Invitrogen™ Supplier No. PA576470
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRP2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Lrp2
Gene Accession No. A2ARV4, P98158, P98164
Gene Alias AI315343; AW536255; b2b1625.2Clo; calcium sensor protein; D230004K18Rik; DBS; Glycoprotein 330; Gp330; Heymann nephritis antigen homolog; LDL receptor related protein 2; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; Lrp2; LRP-2; Megalin
Gene Symbols Lrp2
Host Species Rabbit
Immunogen Recombinant protein of human LRP2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14725, 29216, 4036
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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